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Breez™ (for cell therapy)

The Breez™ bioreactor is the only mL-scale platform that offers fully automated, continuous True Perfusion™ cultures. Sterile, single-use 2mL microbioreactor cassettes with built-in sensor technology and fully integrated fluidics enable the control of critical parameters like temperature, dissolved oxygen, pH, optical density and reduces contamination risk. Bubble and foam free gas transfer in the Erbi Breez™ is accomplished by gas diffusion through a silicone mixing membrane, with barely any shear stress on your precious cells.

With the system which consists of 4 parallel but individual microbioreactors you will be able to perform up to 50x more process development runs from the same limited donor sources. At the same time you are capable of performing complex, multi-step cell therapy process workflows like transduction, washing and more in a fully automated way.

Achieve the maximum yield with minimum usage of resources and begin your process development at an earlier stage = smaller volume in the Breez™ bioreactor. Contact us to "Meet the Breez™ ".

Erbi Biosystems | Breez | POD and bioreactor principle

Erbi Biosystems | Breeze | Animated Setup

Technical data

 

 

FLUID FLOW / VOLUME Working volume: 2 mL
# of Fluid Inputs: 4
Working Flow Rate Range: 0.1-10 VVD
Discrete Input Pump Volume: 0.6 µL +/- 0.1 µL
- Accuracy: +/- 2%
Perfusion Pump Volume: 11.5 µL +/- 1 µL
- Accuracy: +/- 2%
Minimum Sample Volume: 50 µL
PERFUSION FILTER Filter Material: PES
Filter pore size: 1.2 µm
Filter Flow: 1.17 LMH @ 1 vvd
TEMPERATURE Measurement Accuracy: = +/- 0.25°C
Control Range: RT - 50°C
Control Resolution: 0.03°C
DISSOLVED OXYGEN Range: 0-200% air sat
Measurement Accuracy @ 50%: +/- 10%
Resolution: +/- 1%
kLa: Up to 40/hr
pH-MEASUREMENT Measurement Range: 5.5 - 8.5
Measurement  & Control Accuracy @ pH 7: +/- 0.10
CO2 MEASUREMENT Measurement Accuracy: 0.06%
Control Range: 0 bis 30%
Control Resolution: +/- 0.7%
OPTICAL DENSITY Linear Range (CHO): 0-50M cells/mL
Usable Range (CHO): 0-150M cells/mL
Auto Cell Bleed: +/- 10% (typical)
MIKROBIOREACTOR CONSUMABLE Sterilization: Gamma Irradiation
Storage Temperature: Ambient

 

Technical Service


During our business hours, our free telephone support will be glad to assist you in case of any questions. Our Technicians take care of the delivery and installation of original spare parts of the highest quality as well as certified testing, measuring, and control equipment. Our maintenance according to manufacturer specifications includes functional tests, cleaning, accuracy testing with calibration as well as a detailed report. In addition, our maintenance contracts protect your investments and reduce the total cost of ownership.

Detailed information about our support options can be found here.

Erbi Biosystems

Erbi Biosystems provides therapeutic drug manufacturers with tools to accelerate the development of their processes and therapies. Their technology platform includes single-use, mL-scale cell culture, microfluidics, optical sensing, and integrated controls. The Erbi Breez bioreactor is the only mL-scale platform that offers a fully automated, continuous True Perfusion™ culture with more control, increased insights, and all the performance of benchtop bioreactors, altogether with fewer people, less space requirements, and less costs.

More about Erbi Biosystems: https://erbi-bio.com/

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131 employees
10 locations in europe
31 years of experience