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Constant Systems Ltd.
CF1 and CF2 Cell Disruptor
High pressure cell disruption - research to production
The high-pressure homogenizers from Constant Systems Ltd. enable efficient and reproducible lysis of various cell types - such as E. coli and very robust organisms like yeasts, algae and gram-positive bacteria. The product range offers solutions for smaller research experiments up to applications in larger production plants.
- Free selectable pressure range up to 2700 bar (40 kpsi)
- Continuous sample processing at the push of a button
- Robust technology with limited maintenance needs
- No air pressure installation necessary, just an electrical connection
- Efficient cooling of the processed sample with an optional chiller
- Automatic Stop after 3 shots of air
- Bacteria Cultivation
- Microbial Fermentation
- Tissue Disruption
- Homogenizing
- Protein Analysis
- Cell Disruption
- Microbiology
- Biotechnology
- Belgium
- Germany
- Luxembourg
- Netherlands
- Austria
- Switzerland
CF1 and CF2 High-pressure homogenizer
The CF models homogenize cell suspensions continuously with the principle of high pressure relief (known as French-Press-principle). In a free selectable pressure range up to 2700 bar (40 kpsi) all kind of cell suspensions are processed and efficiently disrupted: bacteria, yeast, algae, mammalian and insect cells, fungus etc.. Even at the highest pressure proteins are not denatured, that is why this technology is very beneficial and mostly used for protein isolation. This model is designed for applications in research, development and analytics.
The model CF1 with 1.1 kW compressor power is the smaller table variant and processes sample volumes at a speed of 100 ml/min. Automatic sample supply and hydraulic cooling are optionally available.
For processing even larger volumes, the free-standing model CF2 is available with a process speed of 400 ml/min (24 l/h) and a compressor output of 4 kW.
Viscous samples need the alternative HAIVA model option, which can be built in all four compression versions. These systems have disruption head with an enlarged inlet area for clumpy or high viscous samples, e.g. filamentous fungus or plant cell cultures.
Constant Systems | CF1 / CF2 vs French Press
Technical data
CF1 Cell Disruptor
| Process volume | max 10 L |
| Dead volume | 1 mL (0.3-0.5 mL with OneShot Head Adapter OSHA) |
| Minimal volume | 10 mL (1mL with OSHA) |
| Cycles | 100 mL/min |
| Pressure | up to 2700 bar (40.000 PSI) |
| Sample type | liquid (all states with OSHA) |
| Fixed orifice | yes |
| Sample cooling | yes (optional) |
| Compressed air required | no |
| Dimensions (H x W x D) | 74 x 70 x 62.5 cm |
| Weight | 110-130 kg |
| Add ons | peristaltic process pump, oil cooling circuit |
| Optional extras | OSHA, trolley |
CF2 Cell Disruptor
| Process volume | max 100 L |
| Dead volume | 2 mL (0.3-0.5 mL with OneShot Head Adapter OSHA) |
| Minimal volume | 15 mL (1mL with OSHA) |
| Cycles | 405 mL/min |
| Pressure | up to 2700 bar (40.000 PSI) |
| Sample type | liquid (all states with OSHA) |
| Fixed orifice | yes |
| Sample cooling | yes. Integrated |
| Compressed air required | no |
| Dimensions (H x W x D) | 134 x 70 x 72 cm |
| Weight | 240 kg |
| Add ons | peristaltic process pump integrated |
| Optional extras | OSHA |
Downloads
Technical Service
During our business hours, our free telephone support will be glad to assist you in case of any questions. Our Technicians take care of the delivery and installation of original spare parts of the highest quality as well as certified testing, measuring, and control equipment. Our maintenance according to manufacturer specifications includes functional tests, cleaning, accuracy testing with calibration as well as a detailed report. In addition, our maintenance contracts protect your investments and reduce the total cost of ownership.
Detailed information about our support options can be found here.
Constant Systems Limited was established in 1989 and manufactures und designs high pressure cell disruption equipment. The company has been committed to the design, development, manufacture and aftermarket support of cell disruption equipment, and the hard work and dedication makes it the first-choice supplier for Pharmaceutical/Biotech companies, Research Institutes, Universities and Schools worldwide. Their equipment is used in drug discovery, protein characterization and functional studies of cellular processes. To date, the products of Constant Systems have directly contributed to research published in over 2,000 peer reviewed papers across a range of academic journals, including Nature and the Journal of Biological Chemistry.
More about Constant Systems: https://constantsystems.com/
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