CF1 and CF2 High-pressure homogenizer

The CF models homogenize cell suspensions continuously with the principle of high pressure relief (known as French-Press-principle). In a free selectable pressure range up to 2700 bar (40 kpsi) all kind of cell suspensions are processed and efficiently disrupted: bacteria, yeast, algae, mammalian and insect cells, fungus etc.. Even at the highest pressure proteins are not denatured, that is why this technology is very beneficial and mostly used for protein isolation. This model is designed for applications in research, development and analytics.


The model CF1 with 1.1 kW compressor power is the smaller table variant and processes sample volumes at a speed of 100 ml/min. Automatic sample supply and hydraulic cooling are optionally available.

For processing even larger volumes, the free-standing model CF2 is available with a process speed of 400 ml/min (24 l/h) and a compressor output of 4 kW.


Viscous samples need the alternative HAIVA model option, which can be built in all four compression versions. These systems have disruption head with an enlarged inlet area for clumpy or high viscous samples, e.g. filamentous fungus or plant cell cultures.

Constant Systems | CF1 / CF2 vs French Press

Technical data



CF1 Cell Disruptor

Process volume max 10 L
Dead volume 1 mL (0.3-0.5 mL with OneShot Head Adapter OSHA)
Minimal volume 10 mL (1mL with OSHA)
Cycles 100 mL/min
Pressure up to 2700 bar (40.000 PSI)
Sample type liquid (all states with OSHA)
Fixed orifice yes
Sample cooling yes (optional)
Compressed air required no
Dimensions (H x W x D) 74 x 70 x 62.5 cm
Weight 110-130 kg
Add ons peristaltic process pump, oil cooling circuit
Optional extras OSHA, trolley



CF2 Cell Disruptor

Process volume max 100 L
Dead volume 2 mL (0.3-0.5 mL with OneShot Head Adapter OSHA)
Minimal volume 15 mL (1mL with OSHA)
Cycles 405 mL/min
Pressure up to 2700 bar (40.000 PSI)
Sample type liquid (all states with OSHA)
Fixed orifice yes
Sample cooling yes. Integrated
Compressed air required no
Dimensions  (H x W x D) 134 x 70 x 72 cm
Weight 240 kg
Add ons peristaltic process pump integrated
Optional extras OSHA




Technical Service

During our business hours, our free telephone support will be glad to assist you in case of any questions. Our Technicians take care of the delivery and installation of original spare parts of the highest quality as well as certified testing, measuring, and control equipment. Our maintenance according to manufacturer specifications includes functional tests, cleaning, accuracy testing with calibration as well as a detailed report. In addition, our maintenance contracts protect your investments and reduce the total cost of ownership.

Detailed information about our support options can be found here.

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Constant Systems Ltd.

Constant Systems Limited was established in 1989 and manufactures und designs high pressure cell disruption equipment. The company has been committed to the design, development, manufacture and aftermarket support of cell disruption equipment, and the hard work and dedication makes it the first-choice supplier for Pharmaceutical/Biotech companies, Research Institutes, Universities and Schools worldwide. Their equipment is used in drug discovery, protein characterization and functional studies of cellular processes. To date, the products of Constant Systems have directly contributed to research published in over 2,000 peer reviewed papers across a range of academic journals, including Nature and the Journal of Biological Chemistry.

More about Constant Systems: https://constantsystems.com/


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125 employees
10 locations in europe
32 years of experience