The Cyto-Mine® is an ideal tool for biotherapeutic discovery and cell line development. The Cyto-Mine® is a high throughput, automated platform for the screening and dispensing of single cells. Cells (e.g. B cells, hybridoma or CHO) are encapsulated into picrodroplets and subsequently incubated. In the process of encapsulation, the secretion of proteins, such as monoclonal antibodies, can be quantified by a FRET Assay. An integrated imaging system further ensures single cell origin and thus monoclonality. 

Time consuming and error prone procedures such as limiting dilution and colony picking become redundant as the Cyto-Mine® enables high speed screening, sorting and dispensing of >1000000 cells within 8 hours. Therefore, identifying suitable clones and transfering them to bioreactors happens within hours, not weeks.

Technical data



Cell types B cells, Hybridoma, CHO
Monoclonality >99.9 %
Droplet size pl - nl
Sample volume 0.6 - 2 ml
Sample capacity 104 – 108 samples
Plate format 96-, 384-well
Detection method FRET Assay
Target molecule IgG, Antibody fragments
FRET Assay validated Human, mouse, rat, dog, rabbit
Cyto-Mine® Assay time 8 hours
Consumables Animal Component Free
Pre-sorting no
Cell-cell interaction studies yes
Surface proteins yes
Single molecule Assay yes


Technical Service

During our business hours, our free telephone support will be glad to assist you in case of any questions. Our Technicians take care of the delivery and installation of original spare parts of the highest quality as well as certified testing, measuring, and control equipment. Our maintenance according to manufacturer specifications includes functional tests, cleaning, accuracy testing with calibration as well as a detailed report. In addition, our maintenance contracts protect your investments and reduce the total cost of ownership.

Detailed information about our support options can be found here.

Sphere Fluidics

Sphere Fluidics was founded in 2010 and is an established Life Sciences company, originally spun out from the University of Cambridge. The company initially focused on producing novel biochip systems and providing R&D services. Their systems make the development of new biopharmaceuticals faster and more cost-effective, improve monoclonal antibody screening, cell line development, and overall research efficiency in a number of other applications including synthetic biology, single cell diagnostics, prognostics and single cell genome editing. The Cyto-Mine® Single Cell Analysis System is the flagship product of Sphere Fluidics: the first integrated, benchtop system to automatically analyze, sort and dispense millions of individual cells in just a single day.

More about Sphere Fluidics: https://spherefluidics.com


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131 employees
10 locations in europe
31 years of experience