Manufacturing and scale-up of viral vector and virus-based vaccines can be complicated if intensified cell culture is used for production. Complexities include being able to produce a reliable in-process fingerprint of cell density and size and finding the optimal times for culture infection and virus harvest. Determining those process parameters can help biomanufacturers maintain critical quality attributes of a vaccine while minimizing downstream process steps and associated costs and timelines.

Download this whitepaper that reviews experimental data showing how an in-line technology for capacitance measurement — also known as dielectric spectroscopy (DS) or radiofrequency (RF) impedance spectroscopy — can address many process-monitoring challenges associated with cell culture production of viral vectors and virus-based vaccines.