The controlled release of drugs at precise locations within the body can prevent systemic toxicity and deliver accurate dosages to patients. One of the release mechanisms of therapeutic agents is based on the controlled degradation of the hydrogel that carries the drug. In this case, the decrease in the viscoelastic properties of the hydrogel is proportional to the amount of released drug. Conventional testing instruments are difficult to use difficult to use for evaluating the mechanical properties of hydrogel-based drug release systems during degradation. Because destructive technique, they prevent the re-testing of the same hydrogel sample for long term degradation studies. This leads to the need of more samples to monitor a complete drug release study. Compared to these limitations of conventional methods, the ElastoSens™ Bio is able to capture subtle mechanical changes during degradation before the sample starts to disintegrate. It provides precise measurements of the mechanical properties of dye or drug loaded hydrogels, dependent on the temperature. The ElastoSens Bio can be used to develop or formulate hydrogels to analyze their degradation profile and to test and optimize degradation mechanisms, by enzymatic or chemical reactions. The resulting viscoelastic measurements allows a correlation to the amount of drug release.
Storage modulus (G’) of alginate/gelatin gels at different temperatures (left) and total dye released from composite gels at 24 hours relative to average G’ (right).
Learn more and download our application note "Degradation and drug release of hydrogel-based drug delivery systems"