Pu•MA System™ EC – Automation of assays for spheroids or organoids

The Protein Fluidics’ Pu•MA System EC improves your workflow to automate assays with minimal user handling. The open platform allows you to program complex protocols and increases the reproducibility of your results. The 3D model is placed in a protected chamber with microfluidic liquid exchanges that eliminates mechanical perturbations of 3D cell models. The Pu•MA System EC and Flowchips use valve-less fluidic switching (VLFS) to precisely control fluid movement in the flowchip. Customizable protocols allow easy handling of the device and execute all fluid transfers and incubation steps. The thin clear bottom of the Flowchip is compatible with imaging and standard plate reader systems (384 wells).

The system with it interne temperature and CO2 control maintains the 3D cell models under physiological conditions while the assay steps are in progress, which reduces stress and damage to the cells. for longer cultivation periods, the reservoir flowchip holder allows a humidity of >80% to prevent cell from drying out.


  • Toxicology: Toxicity testing in spheroids with in situ imaging
  • Metabolism: Pu•MA System 3D for single spheroids assays and downstream metabolomics
  • Neuroscience: Phenotypic response to sequential drug addition and analysis in neurospheroids
  • Oncology: Automated organoid assays, sequential drug additions, in situ sampling and in situ imaging


Automate your assay – not only for single organoids

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Technical data



Performance 8 - 32 samples per run
1 - 5 days processing time
10 - 20 µl reagent volume
Operating Conditions  Ambient temperature: 20 - 40 °C
Relative humidiy: 15-95% (non condensing) 
Software Touchscreen driven interface 
Pu•MA Software
Connections 2x USB 2.0 Port (front)
1x RS-232 9 pin serial port (rear)
Electrical Requirements Power requirements: 12 VDC input voltage
110 - 240 VAC at 50-60 Hz
3,3 A current
30 W
Environmental control CO2: 1% -10%
Temperature: +5 °C above ambient to 40 °C
>80% humidity with reservoir 
Physical Dimensions   Width: 305 mm (12 in)
Depth: 355 mm (14 in)
Height: 203 mm (8 in)





3D Cell Flowchips - Pack (4) Protein Fluidics
3D Cell Flowchips - Big Pack (12) Protein Fluidics
Membrane Protein Fluidics
Blanking Chips (4) Protein Fluidics
Flow Chip holder Protein Fluidics
reservoir flow chip holder Protein Fluidics
imaging flow chip holder Protein Fluidics
3D mag loading tray Protein Fluidics


Technical Service

During our business hours, our free telephone support will be glad to assist you in case of any questions. Our Technicians take care of the delivery and installation of original spare parts of the highest quality as well as certified testing, measuring, and control equipment. Our maintenance according to manufacturer specifications includes functional tests, cleaning, accuracy testing with calibration as well as a detailed report. In addition, our maintenance contracts protect your investments and reduce the total cost of ownership.

Detailed information about our support options can be found here.

Logo Protein Fluidics
Protein Fluidics

The privately held company Protein Fluidics Inc. is located in the San Francisco Bay Area. The company is commercializing assay automation platforms using novel microfluidic technologies to accelerate data driven decisions in the Life Sciences. It provides scientists with the latest automation tools to help with the next breakthrough discovery in oncology, diagnostics, and more. The Pu•MA System 3D for your 3D cell models, organoids or spheroids, maintains the cells in our specially designed flowchips to allow for easy media, metabolite or reagent exchanges for your oncology, toxicity, or metabolomics research.

More about Protein Fluidics: https://proteinfluidics.com

125 employees
10 locations in europe
32 years of experience
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