OsmoTECH HT – Osmometer for high sample throughput

The OsmoTECH HT was developed to meet the high throughput needs of cell line development, clone screening, and early process development. It incorporates freezing point depression technology to test osmolality and offers accuracy, precision, and ease-of-use.

The OsmoTECH HT is an automation-friendly, batch plate-based osmometer that offers these features to streamline sample testing while ensuring data integrity in all phases of the testing process:

  • An easy-to-use, menu-driven touchscreen interface to access instrument features.
  • Automated sample pipetting from a 96-well plate format to support your high-volume workflow, eliminating the need for time-consuming manual pipetting into wells and ensuring pipetting consistency.
  • Reliable results using small sample sizes: Only 50 μL per plate well needed to run a standard sample test.
  • Load up to two plates onto the instrument to perform 192 consecutive tests. The instrument can perform up to 1,000 tests before consumables need to be reloaded.
  • Industry-standard support for interfacing with a local area network (LAN).
  • Automated barcode reading of 96-well plates.
  • Customized sampling templates.

Technical data



Sample type Aqueous-based solution
Sample volume  Minimum per well: 50 μl 
Maximum per well: 180 μl
Test time  60 mins for 25 samples 
  3 hr 40 mins for 96 well plate
Sample format  96-well plate
Resolution  1 mOsm/kg H2O
Range (2) 0-2000 mOsm/kg H2O
Accuracy (3)
(AI standards and reference solutions)
Mean value ±3 mOsm/kg H2O from nominal value between 0 and 400 mOsm/kg H2O (1 SD)
Mean value ±1% from nominal value greater than 400 to 2000 mOsm/kg H2O (1 SD)
Within-run repeatability (3)
(AI standards and reference solutions)
Standard deviation ≤3 mOsm/kg H2O between 0 and 400 mOsm/kg H2O
Coefficient of variation ≤1% greater than 400 to 2000 mOsm/kg H2O
Operating conditions  Temperature: 18 °C to 35 °C (64 °F to 95 °F) 
Humidity: 5 to 80% relative humidity (non-condensing)  
Supported languages  Simple Chinese, English, French, German, Italian, Japanese, Korean, Portuguese, Russian, Spanish, Turkish
Storage temperature   -20 °C to +45 °C (-4 °F to +113 °F)
Electrical voltage  100 to 240 VAC (50/60 Hz)
Power consumption 60 Watts
Dimensions (D x W x H)  48.9 cm D x 62.87 cm W x 68.58 cm H 
(19.25” D X 24.75” W X 27 H”)
Net weight  59.7 Kg (131.6 lbs)
Shipping weight  111.9 Kg (246.6 lbs)
Warranty  One-year limited warranty on workmanship and parts








OsmoTECH HT  96-well Plate-Based High-Throughput Micro Osmometer
Convenience Kit
Convenience Kit includes:
• OsmoTECH HT Calibration and Verification Standard Set (3MA635)
• OsmoTECH HT Cleaning Reel (635910)
• OsmoTECH HT System Fluid (635934)
• Clinitrol™ 290 (3MA029)
• OsmoTECH HT 96 Well Plate Kit (635920)
• Osmolality Linearity Set, 5-Level (3LA028)
• Swab Cleaner Kit, Pkg 50 (202850)
• OsmoTECH HT Micro-Sample Tubes, Pkg 1000 (HT1000)
Accessories • Compatible dot matrix printer and cable (135022)
• Printer paper (AN2TP5) 
• Barcode scanner (700056)


Technical Service

During our business hours, our free telephone support will be glad to assist you in case of any questions. Our Technicians take care of the delivery and installation of original spare parts of the highest quality as well as certified testing, measuring, and control equipment. Our maintenance according to manufacturer specifications includes functional tests, cleaning, accuracy testing with calibration as well as a detailed report. In addition, our maintenance contracts protect your investments and reduce the total cost of ownership.

Detailed information about our support options can be found here.

Logo Advanced Instruments
Advanced Instruments

Advanced Instruments is the 65-year Global leader in osmolality testing with experience in developing and manufacturing analytical instruments. With a large install base across 90+ countries in North America, EMEA and Asia Pacific, the company is serving customers in three core markets: biopharma, clinical and food & beverage. Advanced Instruments is dedicated to increasing productivity and ensuring quality in the biopharma, clinical and food & beverage industries. With a focus on innovations that anticipate and overcome customer pain points, they help their customers deliver greater drug yields, better patient care, and ensure food safety.

More about Advanced Instruments: www.aicompanies.com/

125 employees
10 locations in europe
32 years of experience
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