Advanced Instruments
OsmoTECH® XT Osmometer
Single-Sample Micro-Osmometer
The OsmoTECH® XT Single-Sample Micro-Osmometer has been specially developed for the demanding requirements of the biotech industry. It is also used for the measurement of viscous samples. Precise and easy to handle, OsmoTECH® XT fits perfectly into up- and downstream processes. The OsmoTECH® XT is factory calibrated and ready to test.
- Supports 21 CFR Part 11, GMP and EU Annex 11 compliance
- Extended range: 0-4000 mOsm/kg H₂O
- Freezing point depression
- Small sample volume: 20 µl
- Secure and Flexible Data Management
- 3 levels of users access
More osmometers:
Looking for a multi-sample osmometer? Check out the new OsmoTECH HT (96-well plate, high through put) or the OsmoTECH PRO and OsmoPRO MAX. Or a single-sample osmometer for Clinical Chemistry? Check out the Osmo1.
- Biopharmaceutical Quality Control
- Downstream
- Good manufacturing practice (GMP)
- Osmolality
- Single-Use
- Upstream
- Cell Culture
- Cell Biology
- Biotechnology
- Process Control
- Cultured meat
- Alternative proteins
- Belgium
- Denmark
- Netherlands
- Sweden
OsmoTECH® XT – Single sample micro-osmometer
The OsmoTECH® XT Single-Sample Micro-Osmometer has been specifically developed to meet the demanding requirements of the biotech industry. The OsmoTECH® XT measures the widest variety of sample types (high concentration, high viscosity) accurately across bioprocessing and cell & gene therapy workflows with a range of up to 4000mOsm/kg H₂O. With the new OsmoTECH® XT, Advanced Instruments offers a micro osmometer that meets the requirements of 21 CFR part 11 compatibility. Password security, audit trail and access control play an important role.
The integrated barcode scanner simplifies sample identification. The method of freezing point depression offers highest precision and reliability and thus serves to optimize your quality control. With a sample volume of only 20 µl, the osmolality can be determined in direct sampling. The OsmoTECH® XT communicates via Ethernet, USB and can be connected to LIS, OPS and an integrated web server. In addition, it is possible to connect a printer to the instrument. The OsmoTECH® XT is factory calibrated and ready to test.
Advanced Instruments | OsmoTECH XT | Single Sample Micro Osmometer
Advanced Instruments | OsmoTECH XT | Single-Sample Micro-Osmometer Demonstration
Technical data
Sample type | Aqueous solution |
Sample volume | 20 ±1 μL |
Test time | ≤150 seconds (typical) for low range |
≤190 seconds (typical) for high range | |
Sample capacity | Single sample |
Resolution | 1 mOsm/kg H2O |
Range | 0 to 4000 mOsm/kg H2O |
Accuracy | ±2 mOsm/kg H2O from nominal value between 0 and 400 mOsm/kg H2O |
±0.5% from nominal value between 400 and less than 1500 mOsm/kg H2O | |
±1% from nominal value from 1500 to 4000 mOsm/kg H2O | |
Within-Run Repeatability3 | Standard deviation ≤2 mOsm/kg H2O between 0 and 400 mOsm/kg H2O |
Coefficient of variation ≤0.5% between 400 and less than 1500 mOsm/kg H2O | |
Coefficient of variation ≤1% from 1500 to 4000 mOsm/kg H2O | |
Supported languages | Chinese, English, French, German, Italian, Japanese, Korean, Russian, Spanish, Turkish |
Technical Specifications: | |
Storage temperature | -20°C to +45°C (-4°F to +113°F) |
Electrical voltage | 100 to 240 VAC (50/60 Hz) |
Power consumption | 60 Watts |
Dimensions (DxWxH) | Including test kit: 15” x 14” x 11.5” (38 cm x 36 cm x 28 cm) |
Net weight | 5.9 kg (12.9 lbs) |
Shipping weight | 11.4 kg (25 lbs) |
Downloads
Manuals
Brochures
Consumables
AI-3MA000 | 0 mOsm CALIBRATION STANDARD 10x 2 mL | |
AI-3MA005 | 50 mOsm CALIBRATION STANDARD 10x 2 mL | |
AI-3LA011 | 100 mOsm CALIBRATION STANDARD 10x 5 mL | |
AI-3MA020 | 200 mOsm CALIBRATION STANDARD 10x 2 mL | |
AI-3MA003 | 300 mOsm CALIBRATION STANDARD 10x 2 mL | |
AI-3MA040 | 400 mOsm CALIBRATION STANDARD 10x 2 mL | |
AI-3LA051 | 500 mOsm CALIBRATION STANDARD 10x 5 mL | |
AI-3MA085 | 850 mOsm CALIBRATION STANDARD 10x 2 mL | |
AI-3LA091 | 900 mOsm CALIBRATION STANDARD 10x 5 mL | |
AI-3MA100 | 1000 mOsm CALIBRATION STANDARD 10x 2 mL | |
AI-3LA151 | 1500 mOsm CALIBRATION STANDARD 10x 5 mL | |
AI-3MA200 | 2000 mOsm CALIBRATION STANDARD 10x 2 mL | |
AI-3LA301 | 3000 mOsm CALIBRATION STANDARD 10x 5 mL | |
AI-3MA400 | 4000 mOsm CALIBRATION STANDARD 10x 2 mL | |
AI-3MA028 | PROTINOL 3 LEVEL OSMOMETER CONTROL 9x 3 mL | |
AI-3MA029 | CLINITROL 290 REFERENCE SOLUTION 10x 2 mL | |
AI-3LA028 | OSMOLALITY LINEARITY SET 100-2000 mOsm/kg 5x 2x 5 mL | |
AI-XT100 | TEST KIT - 100 TIPS & CLEANERS AND 1 PLUNGER WIRE 1x 100 | |
AI-SK-TECHXT | CONVENIENCE KIT | |
Accessories | ||
AI-235005 | MODEL OsmoTECH XT USER’S GUIDE | |
AI-235006 | SERVICE MANUAL | |
AI-3M0825 | 20- MICROLITER SAMPLER - EASE EJECT | |
AI-135022 | Dot-Matrix Printer | |
AI-AN2TP5 | Printer Paper for Dot-Matrix Printer |
Technical Service
During our business hours, our free telephone support will be glad to assist you in case of any questions. Our Technicians take care of the delivery and installation of original spare parts of the highest quality as well as certified testing, measuring, and control equipment. Our maintenance according to manufacturer specifications includes functional tests, cleaning, accuracy testing with calibration as well as a detailed report. In addition, our maintenance contracts protect your investments and reduce the total cost of ownership.
Detailed information about our support options can be found here.

Advanced Instruments is the 65-year Global leader in osmolality testing with experience in developing and manufacturing analytical instruments. With a large install base across 90+ countries in North America, EMEA and Asia Pacific, the company is serving customers in three core markets: biopharma, clinical and food & beverage. Advanced Instruments is dedicated to increasing productivity and ensuring quality in the biopharma, clinical and food & beverage industries. With a focus on innovations that anticipate and overcome customer pain points, they help their customers deliver greater drug yields, better patient care, and ensure food safety.
More about Advanced Instruments: www.aicompanies.com/
Also interesting for you
![[Translate to EN:] Advanced Instruments OsmoTECH® PRO Osmometer](/fileadmin/user_upload/products/AdvancedInstruments/Osmometer/OsmoTechPro/OsmotechPro.png)
OsmoTECH® PRO Osmometer
The OsmoTECH® PRO from Advanced Instruments is the only multi-sample osmometer designed to support 21 CFR Part 11 compliance, and it offers flexibility to configure these features to your specific needs in Pharma Industry. It is equipped with a 20-position carousel for high sample throughput.
Learn more![[Translate to EN:] Advanced Instruments OsmoPRO Osmometer](/fileadmin/user_upload/products/AdvancedInstruments/Osmometer/OsmoPRO/1_OsmoPRO_.png)
OsmoPRO® Osmometer
The OsmoPRO® offers a convenient carousel design for up to 20 samples and requires a small sample volume of only 20 µl. It is therefore ideally suited for laboratories with medium to high working volumes that prefer batched osmolality testing. Osmolality is determined by freezing point depression.
Learn more