The OsmoTECH® XT Single-Sample Micro-Osmometer has been specifically developed to meet the demanding requirements of the biotech industry. The OsmoTECH® XT measures the widest variety of sample types (high concentration, high viscosity) accurately across bioprocessing and cell & gene therapy workflows with a range of up to 4000mOsm/kg H₂O. With the new OsmoTECH® XT, Advanced Instruments offers a micro osmometer that meets the requirements of 21 CFR part 11 compatibility. Password security, audit trail and access control play an important role.

The integrated barcode scanner simplifies sample identification. The method of freezing point depression offers highest precision and reliability and thus serves to optimize your quality control. With a sample volume of only 20 µl, the osmolality can be determined in direct sampling. The OsmoTECH® XT communicates via Ethernet, USB and can be connected to LIS, OPS and an integrated web server. In addition, it is possible to connect a printer to the instrument. The  OsmoTECH® XT is factory calibrated and ready to test.

Advanced Instruments | OsmoTECH XT | Single Sample Micro Osmometer

Advanced Instruments | OsmoTECH XT | Single-Sample Micro-Osmometer Demonstration

Technical data



Sample volume 20±1 µL
Test time

150 Seconds (typical) for low range
190 Seconds (typical) for high range

Sample capacity Single sample
Range 0 – 4000 mOsm/kg H2O
Communications USB (3), Ethernet (1), Web-Server, OPC-UA, LIS (TCP/IP)







Pipet, 20 µL Advanced Instruments
Printer, Dot Matrix, w/cable Advanced Instruments




Technical Service

During our business hours, our free telephone support will be glad to assist you in case of any questions. Our Technicians take care of the delivery and installation of original spare parts of the highest quality as well as certified testing, measuring, and control equipment. Our maintenance according to manufacturer specifications includes functional tests, cleaning, accuracy testing with calibration as well as a detailed report. In addition, our maintenance contracts protect your investments and reduce the total cost of ownership.

Detailed information about our support options can be found here.

Advanced Instruments

Advanced Instruments is the 65-year Global leader in osmolality testing with experience in developing and manufacturing analytical instruments. With a large install base across 90+ countries in North America, EMEA and Asia Pacific, the company is serving customers in three core markets: biopharma, clinical and food & beverage. Advanced Instruments is dedicated to increasing productivity and ensuring quality in the biopharma, clinical and food & beverage industries. With a focus on innovations that anticipate and overcome customer pain points, they help their customers deliver greater drug yields, better patient care, and ensure food safety.

More about Advanced Instruments: www.aicompanies.com/


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125 employees
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31 years of experience